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Article

G-protein activation by putative antagonists at mutant Thr373Lys alpha2A adrenergic receptors.

British journal of pharmacology - 1 Feb 1999

Wurch T, Colpaert F C, Pauwels P J

Abstract excerpt

1. Replacement of a threonine by a lysine at position 373 in the C-terminal portion of the third intracellular loop of the human alpha2A-adrenergic receptor (alpha2A AR) has been reported to generate a constitutively active mutant receptor in analogy with similar mutations in the alpha1B and beta2 AR (Ren et al., 1993). In the present study, the mutant Thr373Lys alpha2A AR receptor was investigated by measuring...

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Identifiers

PMID: 10193774
DOI: 10.1038/sj.bjp.0702379
PMCID: PMC1571221

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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