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Article

Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors.

Naunyn-Schmiedeberg's archives of pharmacology - 1 Nov 2002

Seifert Roland, Wenzel-Seifert Katharina

Abstract excerpt

The aim of this review is to provide a systematic overview on constitutively active G-protein-coupled receptors (GPCRs), a rapidly evolving area in signal transduction research. We will discuss mechanisms, pharmacological tools and methodological approaches to analyze constitutive activity. The two-state model defines constitutive activity as the ability of a GPCR to undergo agonist-independent isomerization from...

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PMID: 12382069
DOI: 10.1007/s00210-002-0588-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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