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Article

Inverse agonist activity at the alpha(2A)-adrenergic receptor.

Molecular pharmacology - 1 Mar 2001

Wade S M, Lan K, Moore D J, Neubig R R

Abstract excerpt

Constitutive activation of G protein-coupled receptors (GPCRs) is now well recognized and many classical GPCR antagonists have been found to be inverse agonists. For the alpha(2A)-adrenergic receptor (AR) we determine the relative inverse efficacies of a series of antagonists and utilize the extended ternary complex model to estimate the fraction of constitutively active mutant (CAM) receptors in the active...

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Identifiers

PMID: 11179449
DOI: 10.1124/mol.59.3.532

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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