Ligand-induced overexpression of a constitutively active beta2-adrenergic receptor: pharmacological creation of a phenotype in transgenic mice.

doi:10.1073/pnas.94.1.137

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Article

Ligand-induced overexpression of a constitutively active beta2-adrenergic receptor: pharmacological creation of a phenotype in transgenic mice.

Proceedings of the National Academy of Sciences of the United States of America - 7 Jan 1997

Samama P, Bond R A, Rockman H A, Milano C A, Lefkowitz R J

Abstract excerpt

Transgenic overexpression (40- to 100-fold) of the wild-type human beta2-adrenergic receptor in the hearts of mice leads to a marked increase in cardiac contractility, which is apparently due to the low level of spontaneous (i.e., agonist-independent) activity inherent in the receptor. Here we re...

Topics

Adrenergic beta-2 Receptor Antagonists
Adrenergic beta-Antagonists
Animals
Atrial Function
Heart
Humans
Isometric Contraction
Isoproterenol
Ligands
Mice
Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Transgenic

Mutation

Phenotype

Propanolamines

Receptors, Adrenergic, beta-2

Up-Regulation

Ventricular Function, Left

Source

Open in PubMed Open full text

Identifiers

PMID: 8990174
DOI: 10.1073/pnas.94.1.137
PMCID: PMC19258

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8990174-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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