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Article

Constitutively active G protein-coupled receptor mutants: implications on receptor function and drug action.

Assay and drug development technologies - 1 Apr 2003

Cotecchia Susanna, Fanelli Francesca, Costa Tommaso

Abstract excerpt

Mutations of GPCRs can increase their constitutive (agonist-independent) activity. Some of these mutations have been artificially introduced by site-directed mutagenesis; others occur spontaneously in human diseases. The analysis of constitutively active GPCR mutants has attracted a large interest in the past decade, providing an important contribution to our understanding of the molecular mechanisms underlying...

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PMID: 15090196
DOI: 10.1089/15406580360545125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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