Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Constitutive activity and inverse agonism at the alpha1adrenoceptors.

Biochemical pharmacology - 15 Apr 2007

Cotecchia Susanna

Abstract excerpt

Mutations of G protein-coupled receptors (GPCR) can increase their constitutive (agonist-independent) activity. Some of these mutations have been artificially introduced by site-directed mutagenesis, others occur spontaneously in human diseases. The alpha(1B)adrenoceptor was the first GPCR in which point mutations were shown to trigger receptor activation. This article briefly summarizes some of the findings...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chlorocebus aethiops
Share to COS Cells
Share to Cricetinae

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to GTP-Binding Proteins

Share to Protein Conformation

Share to Protein Structure, Secondary

Share to Receptors, Adrenergic, alpha-1

Share to Receptors, G-Protein-Coupled

Source

Identifiers

PMID: 17125741
DOI: 10.1016/j.bcp.2006.10.024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Constitutive activity and inverse agonism at the alpha1adrenoceptors.PMID 17125741Read ↗

Constitutive activity and inverse agonism at the α(₁a) and α(₁b) adrenergic receptor subtypes.Semantic proximity Read ↗

Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors.Semantic proximity Read ↗

Constitutive activation of G protein-coupled receptors and diseases: insights into mechanisms of activation and therapeutics.Semantic proximity Read ↗

Constitutively active G protein-coupled receptor mutants: implications on receptor function and drug action.Semantic proximity Read ↗

Pharmacogenomic and Structural Analysis of Constitutive G Protein–Coupled Receptor ActivitySemantic proximity Read ↗

Recent developments in constitutive receptor activity and inverse agonism, and their potential for GPCR drug discovery.Semantic proximity Read ↗

Constitutive activity in the angiotensin II type 1 receptor: discovery and applications.Semantic proximity Read ↗

Constitutive activity of G-protein coupled receptors: emphasis on serotonin receptors.Semantic proximity Read ↗

Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins.Semantic proximity Read ↗

Characterization of constitutively active mutants of G protein-coupled receptors.Semantic proximity Read ↗

The use of constitutively active receptors for drug discovery at the G protein-coupled receptor gene pool.Semantic proximity Read ↗

Systematic identification of mutations that constitutively activate the angiotensin II type 1A receptor by screening a randomly mutated cDNA library with an original pharmacological bioassay.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.