Article
Constitutively active alpha-1b adrenergic receptor mutants display different phosphorylation and internalization features.
Molecular pharmacology - 1 Feb 1999
Mhaouty-Kodja S, Barak L S, Scheer A, Abuin L, Diviani D, Caron M G, Cotecchia S
Abstract excerpt
We compared the phosphorylation and internalization properties of constitutively active alpha-1b adrenergic receptor (AR) mutants carrying mutations in two distant receptor domains, i.e., at A293 in the distal part of the third intracellular loop and at D142 of the DRY motif lying at the end of t...
Topics
- Adrenergic Agonists
- Amino Acid Substitution
- Animals
- Arrestins
- COS Cells
- Cell Line
- Cricetinae
- Cyclic AMP-Dependent Protein Kinases
- Endocytosis
- Epinephrine
- Gene Expression Regulation
- Green Fluorescent Proteins
- Humans
- Luminescent Proteins
- Microscopy, Fluorescence
- Mutation
- Phosphorylation
- Receptors, Adrenergic, alpha-1