Article
Constitutively active alpha-1b adrenergic receptor mutants display different phosphorylation and internalization features.
Molecular pharmacology - 1 Feb 1999
Mhaouty-Kodja S, Barak L S, Scheer A, Abuin L, Diviani D, Caron M G, Cotecchia S
Abstract excerpt
We compared the phosphorylation and internalization properties of constitutively active alpha-1b adrenergic receptor (AR) mutants carrying mutations in two distant receptor domains, i.e., at A293 in the distal part of the third intracellular loop and at D142 of the DRY motif lying at the end of the third transmembrane domain. For the A293E and A293I mutants the levels of agonist-independent phosphorylation were...
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