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Article

Lessons from constitutively active mutants of G protein-coupled receptors.

Trends in endocrinology and metabolism: TEM - 1 Oct 2002

Parnot Charles, Miserey-Lenkei Stéphanie, Bardin Sabine, Corvol Pierre, Clauser Eric

Abstract excerpt

In the past decade, the concept of constitutive activity has profoundly modified our understanding of G protein-coupled-receptors (GPCRs). Here, we review the contribution of constitutively active mutants (CAMs) to our understanding of three aspects of GPCR physiopathology: (1) GPCR activation is a complex mechanism involving both the release of inactive state conformational constraints, mimicked by most CAMs,...

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PMID: 12217490
DOI: 10.1016/s1043-2760(02)00628-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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