Article
A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated.
Proceedings of the National Academy of Sciences of the United States of America - 29 Mar 1994
Pei G, Samama P, Lohse M, Wang M, Codina J, Lefkowitz R J
Abstract excerpt
The beta 2-adrenergic receptor (beta 2AR) can be constitutively activated by mutations in the third intracellular loop. Whereas the wild-type receptor exists predominantly in an inactive conformation (R) in the absence of agonist, the mutant receptor appears to spontaneously adopt an active conformation (R*). We now demonstrate that not only is the mutant beta 2AR constitutively active, it is also constitutively...
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