Article
A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated.
Proceedings of the National Academy of Sciences of the United States of America - 29 Mar 1994
Pei G, Samama P, Lohse M, Wang M, Codina J, Lefkowitz R J
Abstract excerpt
The beta 2-adrenergic receptor (beta 2AR) can be constitutively activated by mutations in the third intracellular loop. Whereas the wild-type receptor exists predominantly in an inactive conformation (R) in the absence of agonist, the mutant receptor appears to spontaneously adopt an active confo...
Topics
- Adrenergic beta-Agonists
- Amino Acid Sequence
- Animals
- CHO Cells
- Cricetinae
- Dose-Response Relationship, Drug
- GTP Phosphohydrolases
- Gene Expression Regulation
- Isoproterenol
- Molecular Sequence Data
- Mutation