Article
Characterization of constitutively active mutants of G protein-coupled receptors.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2006
Navenot Jean-Marc, Wang Zi-xuan, Peiper Stephen C
Abstract excerpt
The ability of G protein-coupled receptors to transduce signaling typically is induced by the binding of an appropriate ligand (agonist), resulting in a conformational change of the receptor and the subsequent interaction with the G protein heterotrimer. Some mutants of G protein-coupled receptors, known as constitutively active mutants, have the capacity to activate the G protein-signaling cascade even in the...
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