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Article

PAS is a dimerization domain common to Drosophila period and several transcription factors.

Nature - 15 Jul 1993

Huang Z J, Edery I, Rosbash M

Abstract excerpt

Mutations in the period gene product (PER) can shorten or lengthen the circadian rhythms of Drosophila melanogaster, but its biochemical activity has not been established. PER contains a motif of approximately 270 amino acids whose function is unknown (termed PAS) and which is also present in three transcription factors of the basic-helix-loop-helix (bHLH) type, in the D. melanogaster single-minded gene product...

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Identifiers

PMID: 8391649
DOI: 10.1038/364259a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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PAS is a dimerization domain common to Drosophila period and several transcription factors.PMID 8391649Read ↗

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The mPer2 gene encodes a functional component of the mammalian circadian clock.Semantic proximity Read ↗

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The Basic Helix-Loop-Helix-PAS Protein MOP9 Is a Brain-Specific Heterodimeric Partner of Circadian and Hypoxia FactorsSemantic proximity Read ↗

A simple model of circadian rhythms based on dimerization and proteolysis of PER and TIM.Semantic proximity Read ↗

TARANIS interacts with VRILLE and PDP1 to modulate the circadian transcriptional feedback mechanism in <i>Drosophila</i>Semantic proximity Read ↗

Rigid Cooperation of Per1 and Per2 proteins.Semantic proximity Read ↗

Cooperative interaction between phosphorylation sites on PERIOD maintains circadian period in Drosophila.Semantic proximity Read ↗

The dramatic impact of the PER-DBT interaction on circadian timekeeping and temperature compensationSemantic proximity Read ↗

New short period mutations of the Drosophila clock gene per.Semantic proximity Read ↗

Role of the CLOCK protein in the mammalian circadian mechanism.Semantic proximity Read ↗

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