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Article

New short period mutations of the Drosophila clock gene per.

Neuron - 1 Sept 1992

Baylies M K, Vosshall L B, Sehgal A, Young M W

Abstract excerpt

Earlier work has indicated that the period length of Drosophila circadian behavioral rhythms is dependent on the abundance of the period (per) gene product. Increased expression of this gene has been associated with period shortening for both the circadian eclosion (pupal hatching) rhythm and circadian locomotor activity rhythms of adult Drosophila. In this study it is shown that a wide variety of missense...

Topics

Amino Acid Sequence
Animals
Animals, Genetically Modified
Base Sequence
Biological Clocks
Chromosome Mapping
Drosophila
Drosophila Proteins
Genes
Molecular Sequence Data
Mutation
Nuclear Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligonucleotide Probes

Period Circadian Proteins

Proteins

Source

Identifiers

PMID: 1524831
DOI: 10.1016/0896-6273(92)90194-i

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1524831-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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New short period mutations of the Drosophila clock gene per.PMID 1524831Read ↗

The analysis of new short-period circadian rhythm mutants suggests features of D. melanogaster period gene function.Semantic proximity Read ↗

Molecular and behavioral analysis of four period mutants in Drosophila melanogaster encompassing extreme short, novel long, and unorthodox arrhythmic types.Semantic proximity Read ↗

Changes in abundance or structure of the per gene product can alter periodicity of the Drosophila clock.Semantic proximity Read ↗

Temporal phosphorylation of the Drosophila period protein.Semantic proximity Read ↗

Short-period mutations of per affect a double-time-dependent step in the Drosophila circadian clock.Semantic proximity Read ↗

The timSL mutant affects a restricted portion of the Drosophila melanogaster circadian cycle.Semantic proximity Read ↗

Product of per locus of Drosophila shares homology with proteoglycans.Semantic proximity Read ↗

Clock mutations alter developmental timing in Drosophila.Semantic proximity Read ↗

Cooperative interaction between phosphorylation sites on PERIOD maintains circadian period in Drosophila.Semantic proximity Read ↗

Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless.Semantic proximity Read ↗

Cis-combination of the classic per(S) and per(L) mutations results in arrhythmic Drosophila with ectopic accumulation of hyperphosphorylated PERIOD protein.Semantic proximity Read ↗

Altered entrainment and feedback loop function effected by a mutant period protein.Semantic proximity Read ↗

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