Article
Positional cloning and sequence analysis of the Drosophila clock gene, timeless.
Science (New York, N.Y.) - 3 Nov 1995
Myers M P, Wager-Smith K, Wesley C S, Young M W, Sehgal A
Abstract excerpt
The Drosophila genes timeless (tim) and period (per) interact, and both are required for production of circadian rhythms. Here the positional cloning and sequencing of tim are reported. The tim gene encodes a previously uncharacterized protein of 1389 amino acids, and possibly another protein of 1122 amino acids. The arrhythmic mutation tim01 is a 64-base pair deletion that truncates TIM to 749 amino acids....
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