Rigid Cooperation of Per1 and Per2 proteins.

doi:10.1038/srep32769

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Article

Rigid Cooperation of Per1 and Per2 proteins.

Scientific reports - 9 Sept 2016

Tamiya Hiroyuki, Ogawa Sumito, Ouchi Yasuyoshi, Akishita Masahiro

Abstract excerpt

Period circadian clock (Per) genes Per1 and Per2 have essential roles in circadian oscillation. In this study, we identified a new role of Per1-Per2 cooperation, and its mechanism, using our new experimental methods. Under constant light conditions, the period length of Per1 and Per2 knockout mice depended on the copy number ratio of Per1:Per2. We then established a light-emitting diode-based lighting system that...

Topics

Animals
Cell Culture Techniques
Cells, Cultured
Circadian Rhythm
Female
Gene Knockout Techniques
Locomotion
Mice
Models, Biological
Mouse Embryonic Stem Cells
Mutation
NIH 3T3 Cells
Period Circadian Proteins
Photoperiod
Sleep Disorders, Circadian Rhythm

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Identifiers

PMID: 27609640
DOI: 10.1038/srep32769
PMCID: PMC5016722

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