Article
Role of the CLOCK protein in the mammalian circadian mechanism.
Science (New York, N.Y.) - 5 Jun 1998
Gekakis N, Staknis D, Nguyen H B, Davis F C, Wilsbacher L D, King D P, Takahashi J S, Weitz C J
Abstract excerpt
The mouse Clock gene encodes a bHLH-PAS protein that regulates circadian rhythms and is related to transcription factors that act as heterodimers. Potential partners of CLOCK were isolated in a two-hybrid screen, and one, BMAL1, was coexpressed with CLOCK and PER1 at known circadian clock sites i...
Topics
- ARNTL Transcription Factors
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- Biological Clocks
- CLOCK Proteins
- Cell Cycle Proteins
- Circadian Rhythm
- Cloning, Molecular
- Cricetinae
- DNA
- Dimerization
- Feedback
- Gene Expression
- Helix-Loop-Helix Motifs
- Male
- Mesocricetus
- Mice
- Mutation