Isolation of timeless by PER protein interaction: defective interaction between timeless protein and long-period mutant PERL.

doi:10.1126/science.270.5237.811

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Article

Isolation of timeless by PER protein interaction: defective interaction between timeless protein and long-period mutant PERL.

Science (New York, N.Y.) - 3 Nov 1995

Gekakis N, Saez L, Delahaye-Brown A M, Myers M P, Sehgal A, Young M W, Weitz C J

Abstract excerpt

The period (per) gene likely encodes a component of the Drosophila circadian clock. Circadian oscillations in the abundance of per messenger RNA and per protein (PER) are thought to arise from negative feedback control of per gene transcription by PER. A recently identified second clock locus, timeless (tim), apparently regulates entry of PER into the nucleus. Reported here are the cloning of complementary DNAs...

Topics

Animals
Biological Clocks
Cell Nucleus
Circadian Rhythm
Cloning, Molecular
Cytoplasm
DNA, Complementary
Drosophila Proteins
Drosophila melanogaster
Feedback
Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Insect

Mutation

Nuclear Proteins

Period Circadian Proteins

Proteins

Recombinant Fusion Proteins

Temperature

Source

Open in PubMed

Identifiers

PMID: 7481773
DOI: 10.1126/science.270.5237.811

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7481773-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Isolation of timeless by PER protein interaction: defective interaction between timeless protein and long-period mutant PERL.PMID 7481773Read ↗

The timSL mutant of the Drosophila rhythm gene timeless manifests allele-specific interactions with period gene mutants.Semantic proximity Read ↗

Post-translational regulation and nuclear entry of TIMELESS and PERIOD are affected in new timeless mutant.Semantic proximity Read ↗

Block in nuclear localization of period protein by a second clock mutation, timeless.Semantic proximity Read ↗

Positional cloning and sequence analysis of the Drosophila clock gene, timeless.Semantic proximity Read ↗

A TIMELESS-independent function for PERIOD proteins in the Drosophila clock.Semantic proximity Read ↗

The double-time protein kinase regulates the subcellular localization of the Drosophila clock protein period.Semantic proximity Read ↗

Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timeless.Semantic proximity Read ↗

CK2 inhibits TIMELESS nuclear export and modulates CLOCK transcriptional activity to regulate circadian rhythmsSemantic proximity Read ↗

Short-period mutations of per affect a double-time-dependent step in the Drosophila circadian clock.Semantic proximity Read ↗

TIMELESS is an important mediator of CK2 effects on circadian clock function in vivo.Semantic proximity Read ↗

The timSL mutant affects a restricted portion of the Drosophila melanogaster circadian cycle.Semantic proximity Read ↗

A PER/TIM/DBT interval timer for Drosophila's circadian clock.Semantic proximity Read ↗

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