Article
Mechanism of action of quinolones against Escherichia coli DNA gyrase.
Antimicrobial agents and chemotherapy - 1 Apr 1993
Yoshida H, Nakamura M, Bogaki M, Ito H, Kojima T, Hattori H, Nakamura S
Abstract excerpt
The mechanism of action of quinolones was investigated by use of various DNA gyrases reconstituted from wild-type and mutant GyrA and GyrB proteins of Escherichia coli. The quinolone sensitivities of the DNA supercoiling activity of the gyrases were generally parallel to the quinolone susceptibil...
Topics
- Anti-Infective Agents
- Bacterial Proteins
- DNA Gyrase
- DNA Topoisomerases, Type II
- DNA, Bacterial
- DNA, Superhelical
- Electrophoresis, Polyacrylamide Gel
- Enoxacin
- Escherichia coli
- Indicators and Reagents
- Mutation
- Plasmids
- Topoisomerase II Inhibitors
- Transformation, Genetic