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Article

DNA gyrase and topoisomerase IV on the bacterial chromosome: quinolone-induced DNA cleavage.

Journal of molecular biology - 17 May 1996

Chen C R, Malik M, Snyder M, Drlica K

Abstract excerpt

DNA gyrase, the bacterial enzyme that supercoils DNA, is trapped on chromosomal DNA by the 4-quinolone compounds, as drug-gyrase complexes that contain DNA breaks. Examination of chromosomal DNA extracted from Escherichia coli indicated that bacteriostatic concentrations of oxolinic acid trap gyr...

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Source

Identifiers

PMID: 8636997
DOI: 10.1006/jmbi.1996.0274

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-8636997-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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