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Article

Quinolone-binding pocket of DNA gyrase: role of GyrB.

Antimicrobial agents and chemotherapy - 1 Jun 2002

Heddle Jonathan, Maxwell Anthony

Abstract excerpt

DNA gyrase is a prokaryotic type II topoisomerase and a major target of quinolone antibacterials. The majority of mutations conferring resistance to quinolones arise within the quinolone resistance-determining region of GyrA close to the active site (Tyr(122)) where DNA is bound and cleaved. However, some quinolone resistance mutations are known to exist in GyrB. Present structural data suggest that these...

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Identifiers

PMID: 12019094
DOI: 10.1128/AAC.46.6.1805-1815.2002
PMCID: PMC127264

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Source receipt: pubmed, retrieved 7 Sept 2026.

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