Article
Mechanism of plasmid-mediated quinolone resistance.
Proceedings of the National Academy of Sciences of the United States of America - 16 Apr 2002
Tran John H, Jacoby George A
Abstract excerpt
Quinolones are potent antibacterial agents that specifically target bacterial DNA gyrase and topoisomerase IV. Widespread use of these agents has contributed to the rise of bacterial quinolone resistance. Previous studies have shown that quinolone resistance arises by mutations in chromosomal genes. Recently, a multiresistance plasmid was discovered that encodes transferable resistance to quinolones. We have...
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