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Article

Mechanism of inhibition of DNA gyrase by cyclothialidine, a novel DNA gyrase inhibitor.

Antimicrobial agents and chemotherapy - 1 Sept 1994

Nakada N, Gmünder H, Hirata T, Arisawa M

Abstract excerpt

We investigated how cyclothialidine (Ro 09-1437), a novel DNA gyrase inhibitor belonging to a new chemical class of compounds, acts to inhibit Escherichia coli DNA gyrase. Cyclothialidine up to 100 micrograms/ml showed no effect on DNA gyrase when linear DNA was used as a substrate. Under the same conditions, quinolones, which inhibit the resealing reaction of DNA gyrase, caused a decrease in the amount of linear...

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Identifiers

PMID: 7811004
DOI: 10.1128/AAC.38.9.1966
PMCID: PMC284669

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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