Article
Mechanism of inhibition of DNA gyrase by cyclothialidine, a novel DNA gyrase inhibitor.
Antimicrobial agents and chemotherapy - 1 Sept 1994
Nakada N, Gmünder H, Hirata T, Arisawa M
Abstract excerpt
We investigated how cyclothialidine (Ro 09-1437), a novel DNA gyrase inhibitor belonging to a new chemical class of compounds, acts to inhibit Escherichia coli DNA gyrase. Cyclothialidine up to 100 micrograms/ml showed no effect on DNA gyrase when linear DNA was used as a substrate. Under the sam...
Topics
- 4-Quinolones
- Adenosine Triphosphatases
- Adenosine Triphosphate
- Anti-Bacterial Agents
- Anti-Infective Agents
- Binding, Competitive
- Carbon Radioisotopes
- Coumarins
- DNA Topoisomerases, Type II
- DNA, Bacterial
- DNA, Superhelical
- Escherichia coli
- Mutation
- Peptides, Cyclic
- Topoisomerase II Inhibitors