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Article

Inhibitory activities of quinolones against DNA gyrase and topoisomerase IV purified from Staphylococcus aureus.

Antimicrobial agents and chemotherapy - 1 Nov 1997

Tanaka M, Onodera Y, Uchida Y, Sato K, Hayakawa I

Abstract excerpt

In order to clarify the mechanism of action of quinolones against Staphylococcus aureus, GrlA and GrlB proteins of topoisomerase IV encoded by genes with or without mutations were purified separately as fusion proteins with maltose-binding protein in Escherichia coli. The reconstituted enzymes showed ATP-dependent decatenation and relaxing activities but had no supercoiling activity. The inhibitory effects of...

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Identifiers

PMID: 9371334
DOI: 10.1128/AAC.41.11.2362
PMCID: PMC164129

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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