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Article

Unique biological properties and molecular mechanism of 5,6-bridged quinolones.

Antimicrobial agents and chemotherapy - 1 Aug 2003

Macinga David R, Renick Paul J, Makin Kelly M, Ellis David H, Kreiner Allison A, Li Min, Rupnik Kirk J, Kincaid Erica M, Wallace Cynthia D, Ledoussal Benoit, Morris Timothy W

Abstract excerpt

We have characterized an early series of 5,6-bridged dioxinoquinolones which behaved strikingly different from typical quinolones. The 5,6-bridged dioxinoquinolones inhibited Escherichia coli DNA gyrase supercoiling activity but, unlike typical quinolones, failed to stimulate gyrase-dependent cleavable complex formation. Analogous unsubstituted compounds stimulated cleavable complex formation but were...

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Identifiers

PMID: 12878515
DOI: 10.1128/AAC.47.8.2526-2537.2003
PMCID: PMC166059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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