Article
The mechanism of inhibition of topoisomerase IV by quinolone antibacterials.
The Journal of biological chemistry - 16 Oct 1998
Khodursky A B, Cozzarelli N R
Abstract excerpt
Topoisomerase IV (Topo IV) is a mediator of quinolone toxicity in bacteria. In this work, we demonstrate that norfloxacin, a model quinolone, converts Escherichia coli Topo IV into a poisonous adduct on DNA as opposed to inhibiting topoisomerase activity. Norfloxacin inhibition of Topo IV induces...
Topics
- Adenosine Triphosphatases
- Anti-Infective Agents
- Chromosomes, Bacterial
- DNA Adducts
- DNA Damage
- DNA Helicases
- DNA Repair
- DNA Replication
- DNA Topoisomerase IV
- DNA Topoisomerases, Type II
- Escherichia coli
- Escherichia coli Proteins
- Exodeoxyribonuclease V
- Exodeoxyribonucleases
- Models, Genetic
- Mutation
- Norfloxacin
- Plasmids