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Article

The mechanism of inhibition of topoisomerase IV by quinolone antibacterials.

The Journal of biological chemistry - 16 Oct 1998

Khodursky A B, Cozzarelli N R

Abstract excerpt

Topoisomerase IV (Topo IV) is a mediator of quinolone toxicity in bacteria. In this work, we demonstrate that norfloxacin, a model quinolone, converts Escherichia coli Topo IV into a poisonous adduct on DNA as opposed to inhibiting topoisomerase activity. Norfloxacin inhibition of Topo IV induces a slow decline in DNA synthesis that parallels cell death. Treatment of cells with a lethal concentration of the...

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PMID: 9765303
DOI: 10.1074/jbc.273.42.27668

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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