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Article

Mechanism of quinolone mutagenicity in bacteria.

Mutation research - 1 May 1991

Gocke E

Abstract excerpt

Gyrase inhibitors of the quinolone type are genotoxic in bacteria. A functioning excision-repair system is needed to show the mutagenic activity in the Ames tester strains. The antibiotics do not interact with DNA directly but induce the gyrase enzyme to cleave the DNA with protein covalently bound at the site-specific double-strand scission. A prominent site of action is shown to be located at a distance of...

Topics

Anti-Infective Agents
Blotting, Southern
Ciprofloxacin
DNA Topoisomerases, Type II
Enrofloxacin
Escherichia coli
Fleroxacin
Fluoroquinolones
Genes, Bacterial
Mutation
Novobiocin
Ofloxacin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oxolinic Acid

Quinolones

Salmonella

Source

Identifiers

PMID: 1851537
DOI: 10.1016/0027-5107(91)90095-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1851537-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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