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Article

Topoisomerase IV is a target of quinolones in Escherichia coli.

Proceedings of the National Academy of Sciences of the United States of America - 5 Dec 1995

Khodursky A B, Zechiedrich E L, Cozzarelli N R

Abstract excerpt

We have demonstrated that, in Escherichia coli, quinolone antimicrobial agents target topoisomerase IV (topo IV). The inhibition of topo IV becomes apparent only when gyrase is mutated to quinolone resistance. In such mutants, these antibiotics caused accumulation of replication catenanes, which is diagnostic of a loss of topo IV activity. Mutant forms of topo IV provided an additional 10-fold resistance to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 8524852
DOI: 10.1073/pnas.92.25.11801
PMCID: PMC40490

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Source receipt: pubmed, retrieved 7 Sept 2026.

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