Article
Effects of ciprofloxacin on plasmid DNA supercoiling of Escherichia coli topoisomerase I and gyrase mutants.
Antimicrobial agents and chemotherapy - 1 Jan 1991
Aleixandre V, Herrera G, Urios A, Blanco M
Abstract excerpt
Changes in plasmid DNA supercoiling were measured following treatment of Escherichia coli cells, carrying topoisomerase mutations, with the quinolone ciprofloxacin. In quinolone-susceptible cells (top+ gyr+) as well as in topA mutants and in gyrB mutants, plasmid DNA was relaxed after the additio...
Topics
- Ciprofloxacin
- DNA Topoisomerases, Type I
- DNA Topoisomerases, Type II
- DNA, Superhelical
- Drug Resistance, Microbial
- Escherichia coli
- Mutation
- Nucleic Acid Conformation
- Plasmids
- Quinolines