Article
Characterization of the switch of kinetoplast DNA minicircle dominance during development and reversion of drug resistance in Leishmania.
Molecular and biochemical parasitology - 1 Apr 1993
Lee S T, Tarn C, Chang K P
Abstract excerpt
To characterize the differences between kDNA minicircles of drug-resistant Leishmania mexicana amazonensis variants that show nuclear DNA amplification and minicircles of variants without nuclear DNA amplification, we sequenced minicircles from repeatedly cloned parasites. The dominant minicircle...
Topics
- Animals
- Arsenic
- Arsenites
- Base Sequence
- DNA, Circular
- DNA, Kinetoplast
- DNA, Protozoan
- Drug Resistance
- Genes, Protozoan
- Genes, Switch
- Genetic Variation
- Leishmania mexicana
- Microscopy, Electron
- Molecular Sequence Data
- Sequence Homology, Nucleic Acid
- Tunicamycin