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Article

Characterization of the switch of kinetoplast DNA minicircle dominance during development and reversion of drug resistance in Leishmania.

Molecular and biochemical parasitology - 1 Apr 1993

Lee S T, Tarn C, Chang K P

Abstract excerpt

To characterize the differences between kDNA minicircles of drug-resistant Leishmania mexicana amazonensis variants that show nuclear DNA amplification and minicircles of variants without nuclear DNA amplification, we sequenced minicircles from repeatedly cloned parasites. The dominant minicircles from arsenite- and tunicamycin-resistant parasites with DNA amplification were found to preexist as minor conserved...

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PMID: 8386802
DOI: 10.1016/0166-6851(93)90041-u

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