Article
Leishmania amazonensis: multidrug resistance in vinblastine-resistant promastigotes is associated with rhodamine 123 efflux, DNA amplification, and RNA overexpression of a Leishmania mdr1 gene.
Experimental parasitology - 1 Dec 1995
Gueiros-Filho F J, Viola J P, Gomes F C, Farina M, Lins U, Bertho A L, Wirth D F, Lopes U G
Abstract excerpt
A vinblastine-resistant Leishmania amazonensis cell line (RV100) which exhibits cross-resistance to the unrelated drug adriamycin, and thus is considered to be multidrug resistant (MDR), was isolated after stepwise selection with increasing concentrations of vinblastine. This phenotype was partia...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Antiprotozoal Agents
- Cell Line
- DNA, Protozoan
- Doxorubicin
- Drug Resistance, Multiple
- Electrophoresis, Gel, Pulsed-Field
- Gene Amplification
- Genes, Protozoan
- Leishmania
- Molecular Probe Techniques
- Phenotype