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Article

RNA interference of a trypanosome topoisomerase II causes progressive loss of mitochondrial DNA.

The EMBO journal - 3 Sept 2001

Wang Z, Englund P T

Abstract excerpt

We studied the function of a Trypanosoma brucei topoisomerase II using RNA interference (RNAi). Expression of a topoisomerase II double-stranded RNA as a stem-loop caused specific degradation of mRNA followed by loss of protein. After 6 days of RNAi, the parasites' growth rate declined and the cells subsequently died. The most striking phenotype upon induction of RNAi was the loss of kinetoplast DNA (kDNA), the...

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Topics

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Share to DNA, Kinetoplast
Share to DNA, Mitochondrial
Share to DNA, Protozoan

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Replication

Share to DNA Topoisomerases, Type II

Share to RNA, Double-Stranded

Share to RNA, Protozoan

Share to Trypanosoma brucei brucei

Source

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Identifiers

PMID: 11532932
DOI: 10.1093/emboj/20.17.4674
PMCID: PMC125608

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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