Article
Characterization of sequence changes in kinetoplast DNA maxicircles of drug-resistant Leishmania.
Molecular and biochemical parasitology - 1 Dec 1992
Lee S T, Tarn C, Wang C Y
Abstract excerpt
We have compared kinetoplast DNA maxicircles of tunicamycin- and arsenite-resistant variants of repeatedly cloned Leishmania mexicana amazonensis showing DNA amplification with wild-type and arsenite-resistant variants of the same lineage that do not show DNA amplification. DNA restriction patter...
Topics
- Amino Acid Sequence
- Animals
- Arsenic
- Arsenites
- Base Sequence
- Clone Cells
- Cloning, Molecular
- Cytochrome b Group
- DNA, Circular
- DNA, Kinetoplast
- DNA, Protozoan
- Drug Resistance
- Genetic Variation
- Leishmania mexicana
- Molecular Sequence Data
- Organelles
- Sequence Homology, Amino Acid
- Tunicamycin