Altered drug membrane permeability in a multidrug-resistant Leishmania tropica line.

doi:10.1016/s0006-2952(97)00385-7

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Altered drug membrane permeability in a multidrug-resistant Leishmania tropica line.

Biochemical pharmacology - 15 Jan 1998

Chiquero M J, Pérez-Victoria J M, O'Valle F, González-Ros J M, del Moral R G, Ferragut J A, Castanys S, Gamarro F

Abstract excerpt

We selected a Leishmania tropica cell line resistant to daunomycin (DNM) that presents a multidrug-resistant (MDR) phenotype characterized by overexpression of a P-glycoprotein of 150 kDa. The resistant line overexpressed an MDR-like gene, called ltrmdr1, located in an extrachromosomal circular D...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Animals
Cell Membrane
Cell Membrane Permeability
Daunorubicin
Doxorubicin
Drug Resistance, Multiple
Kinetics
Leishmania tropica
Phenotype
Puromycin
Vinblastine

Source

Open in PubMed

Identifiers

PMID: 9448735
DOI: 10.1016/s0006-2952(97)00385-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9448735-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics