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The <i>Trypanosoma cruzi</i> kinetoplast DNA minicircle sequences transfer biomarker of the multidrug treatment of Chagas disease

2021-12-17

Abstract excerpt

<h4>Background</h4> The Trypanosoma cruzi infection renders the transfer of the mitochondrion kinetoplast DNA minicircle sequences into the host’s genome. The Aves are refractory to the infection, but chicks hatched from the T. cruzi inoculated eggs integrate the DNA minicircle sequences into the germ line cells. Rabbits, mice and chickens with the minicircle sequences mutations develop the Chagas cardiomyopath...

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Literature Corpus work
de5ad491-909e-5583-b0a2-9fa1806af542
DOI
10.1101/2021.12.16.473091
Open publication

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