Article
Genotypic polymorphisms in experimental metastatic dermal leishmaniasis.
Molecular and biochemical parasitology - 1 Feb 1995
Pacheco R S, Martinez J E, Valderrama L, Momen H, Saravia N G
Abstract excerpt
Molecular karyotype and kDNA restriction analyses were utilized to examine the genetic heterogeneity and plasticity of the Leishmania (Viannia) guyanensis strain WHI/BR/78/M5313, composed of metastatic and non-metastatic populations. Cloning revealed that the strain was constituted by multiple cl...
Topics
- Animals
- Cricetinae
- DNA, Kinetoplast
- Disease Models, Animal
- Genetic Variation
- Genotype
- Leishmania guyanensis
- Leishmaniasis, Mucocutaneous
- Male
- Mesocricetus
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length