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Article

Genotypic polymorphisms in experimental metastatic dermal leishmaniasis.

Molecular and biochemical parasitology - 1 Feb 1995

Pacheco R S, Martinez J E, Valderrama L, Momen H, Saravia N G

Abstract excerpt

Molecular karyotype and kDNA restriction analyses were utilized to examine the genetic heterogeneity and plasticity of the Leishmania (Viannia) guyanensis strain WHI/BR/78/M5313, composed of metastatic and non-metastatic populations. Cloning revealed that the strain was constituted by multiple closely related populations that were distinguishable by restriction fragment polymorphisms in kDNA. Size polymorphisms...

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PMID: 7770084
DOI: 10.1016/0166-6851(94)00212-6

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