Selective amplification of maxicircle classes during the life cycle of Leishmania major.

doi:10.1016/j.molbiopara.2009.01.014

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Article

Selective amplification of maxicircle classes during the life cycle of Leishmania major.

Molecular and biochemical parasitology - 1 Jun 2009

Flegontov Pavel N, Zhirenkina Ekaterina N, Gerasimov Evgeny S, Ponirovsky Evgeny N, Strelkova Margarita V, Kolesnikov Alexander A

Abstract excerpt

The kinetoplast genome contains several thousands of minicircles of various sequence classes and several scores of maxicircles. We demonstrated that maxicircles are heterogeneous in clonal cultures of Leishmania major, and, therefore, probably heterogeneous (heteroplasmic) within the kinetoplast. Sequence heterogeneity was observed in a non-coding fragment upstream of the 12S rRNA gene. We identified about 20...

Topics

Animals
Clone Cells
DNA, Kinetoplast
Genetic Markers
Genetic Variation
Leishmania major
Life Cycle Stages
Molecular Sequence Data
Phylogeny

Source

Open in PubMed

Identifiers

PMID: 19428661
DOI: 10.1016/j.molbiopara.2009.01.014

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