Article
A muscle cell variant defective in glycosaminoglycan biosynthesis forms nerve-induced but not spontaneous clusters of the acetylcholine receptor and the 43 kDa protein.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Feb 1993
Gordon H, Lupa M, Bowen D, Hall Z
Abstract excerpt
Myotubes of the C2 mouse muscle cell line form clusters of ACh receptors (AChRs) at apparently random sites along their length when cultured alone, and near sites of nerve-muscle contact when cocultured with neurons. We find in aneural cultures that myotubes of a C2 variant, S27, which is defecti...
Topics
- Agrin
- Animals
- Cell Line
- Cell Membrane
- Collagen
- Genetic Variation
- Glycosaminoglycans
- Laminin
- Mice
- Molecular Weight
- Muscle Proteins
- Muscles
- Nerve Tissue Proteins
- Neuromuscular Junction
- Proteoglycans