Article
The function of cortactin in the clustering of acetylcholine receptors at the vertebrate neuromuscular junction.
PloS one - 29 Dec 2009
Madhavan Raghavan, Gong Zhuolin L, Ma Jin Jin, Chan Ariel W S, Peng H Benjamin
Abstract excerpt
BACKGROUND: Postsynaptic enrichment of acetylcholine receptors (AChRs) at the vertebrate neuromuscular junction (NMJ) depends on the activation of the muscle receptor tyrosine MuSK by neural agrin. Agrin-stimulation of MuSK is known to initiate an intracellular signaling cascade that leads to the clustering of AChRs in an actin polymerization-dependent manner, but the molecular steps which link MuSK activation to...
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