Article
RNA splicing regulates agrin-mediated acetylcholine receptor clustering activity on cultured myotubes.
Neuron - 1 Jun 1992
Ferns M, Hoch W, Campanelli J T, Rupp F, Hall Z W, Scheller R H
Abstract excerpt
Agrin is a component of the synaptic basal lamina that induces the clustering of acetylcholine receptors (AChRs) on muscle fibers. A region near the carboxyl terminus of the protein exists in four forms that are generated by alternative RNA splicing. All four alternatively spliced forms of agrin are active in inducing AChR clusters on rat primary and C2-derived muscle fibers. In contrast, only two forms of the...
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