Article
RNA splicing regulates agrin-mediated acetylcholine receptor clustering activity on cultured myotubes.
Neuron - 1 Jun 1992
Ferns M, Hoch W, Campanelli J T, Rupp F, Hall Z W, Scheller R H
Abstract excerpt
Agrin is a component of the synaptic basal lamina that induces the clustering of acetylcholine receptors (AChRs) on muscle fibers. A region near the carboxyl terminus of the protein exists in four forms that are generated by alternative RNA splicing. All four alternatively spliced forms of agrin...
Topics
- Agrin
- Animals
- Chick Embryo
- Culture Techniques
- Genetic Variation
- Mice
- Muscles
- Nerve Tissue Proteins
- RNA Splicing
- Rats
- Receptor Aggregation
- Receptors, Cholinergic
- Synaptic Membranes