Article
Dystroglycan binds nerve and muscle agrin.
Neuron - 1 Jul 1994
Sugiyama J, Bowen D C, Hall Z W
Abstract excerpt
Neurally released agrin is thought to cluster acetylcholine receptors (AChRs) and other synaptic proteins in the postsynaptic membrane during synaptogenesis at the neuromuscular junction. We have examined the binding of nerve and muscle agrins, which have dramatically different abilities to cluster AChRs, to the membrane proteins of Torpedo electric organ and C2 myotubes. Both bound with approximately nanomolar...
Topics
- Agrin
- Animals
- Antibodies, Monoclonal
- Cell Line
- Cell Membrane
- Cytoskeletal Proteins
- Dystroglycans
- Electric Organ
- Membrane Glycoproteins
- Mice
- Muscles
- Mutation