Article
The involvement of calcineurin in acetylcholine receptor redistribution in muscle.
Molecular and cellular neurosciences - 1 Aug 2003
Madhavan Raghavan, Zhao Xiaotao T, Chan Frances, Wu Zhenguo, Peng H Benjamin
Abstract excerpt
In this study the intracellular signaling involved in acetylcholine receptor (AChR) redistribution in muscle was investigated. In cultured Xenopus embryonic muscle cells, both the dispersal of preexisting AChR clusters and the induction of new AChR clusters by growth factor-coated polystyrene beads were inhibited by two specific antagonists of the ser/thr phosphatase calcineurin (CaN), Cyclosporin A, (CsA) and...
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