Article
A correlative study of p53 protein alteration and p53 gene mutation in glioblastoma multiforme.
Brain pathology (Zurich, Switzerland) - 1 Jul 1993
Newcomb E W, Madonia W J, Pisharody S, Lang F F, Koslow M, Miller D C
Abstract excerpt
The p53 tumor suppressor gene is frequently mutated in glioblastomas. Mutations within the p53 gene often result in aberrant expression of the p53 protein leading to protein accumulation within the nucleus of the cells which can be detected by immunochemistry. Many studies have correlated alterat...
Topics
- Antibodies, Monoclonal
- Base Sequence
- Blotting, Southern
- Brain Neoplasms
- Exons
- Gene Amplification
- Genes, p53
- Glioblastoma
- Humans
- Immunohistochemistry
- Molecular Sequence Data
- Mutation
- Polymorphism, Genetic
- Tumor Suppressor Protein p53