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Mutations of the <i>p53</i> tumor suppressor gene in neoplasms of the human nervous system

1 Jan 1993

Abstract excerpt

A variety of neoplasms of the human nervous system were analyzed for the presence of mutations in the p53 tumor suppressor gene. DNA was extracted from frozen or formalin-fixed, paraffin-embedded material. Single-strand conformation polymorphism (SSCP) analysis for exons 5-8 was followed by direct DNA sequencing. Mutations leading to an amino acid change were found in three of 11 (27%) low-grade (World Health...

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PMID: 8397797
DOI: 10.1002/mc.2940080203

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