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Article

Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse.

Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1993

Michalska A E, Choo K H

Abstract excerpt

We report the generation of transgenic mice deficient in the metallothionein MT-I and MT-II genes. The mutations were introduced into embryonic stem cells by homologous recombination. Chimeric mice resulting from the targeted embryonic stem cells transmitted the disrupted alleles through their germ line. Homozygous animals were born alive and appeared phenotypically normal and fertile. Absence of MT proteins was...

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Identifiers

PMID: 8367468
DOI: 10.1073/pnas.90.17.8088
PMCID: PMC47293

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