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Article

Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1.

The EMBO journal - 15 May 1998

Günes C, Heuchel R, Georgiev O, Müller K H, Lichtlen P, Blüthmann H, Marino S, Aguzzi A, Schaffner W

Abstract excerpt

We have shown previously that the heavy metal-responsive transcriptional activator MTF-1 regulates the basal and heavy metal-induced expression of metallothioneins. To investigate the physiological function of MTF-1, we generated null mutant mice by targeted gene disruption. Embryos lacking MTF-1 die in utero at approximately day 14 of gestation. They show impaired development of hepatocytes and, at later stages,...

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Identifiers

PMID: 9582278
DOI: 10.1093/emboj/17.10.2846
PMCID: PMC1170625

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Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1.PMID 9582278Read ↗

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