Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1.

doi:10.1093/emboj/17.10.2846

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Article

Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1.

The EMBO journal - 15 May 1998

Günes C, Heuchel R, Georgiev O, Müller K H, Lichtlen P, Blüthmann H, Marino S, Aguzzi A, Schaffner W

Abstract excerpt

We have shown previously that the heavy metal-responsive transcriptional activator MTF-1 regulates the basal and heavy metal-induced expression of metallothioneins. To investigate the physiological function of MTF-1, we generated null mutant mice by targeted gene disruption. Embryos lacking MTF-1...

Topics

Animals
Cadmium
Cells, Cultured
DNA-Binding Proteins
Dipeptides
Edema
Embryonic and Fetal Development
Female
Fetal Diseases
Fibroblasts
Gene Expression Regulation
Gene Targeting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glutathione Synthase

Hydrogen Peroxide

Liver

Liver Diseases

Male

Mice

Source

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Identifiers

PMID: 9582278
DOI: 10.1093/emboj/17.10.2846
PMCID: PMC1170625

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9582278-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1.PMID 9582278Read ↗

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