Article

A mouse model to study glutathione limitation <i>in vivo</i>

2024-01-09

Abstract excerpt

Glutathione (GSH) is a highly abundant tripeptide thiol that performs diverse protective and biosynthetic functions in cells. While changes in GSH availability are linked to many diseases, including cancer and neurodegenerative disorders, determining the function of GSH in physiology and disease has been challenging due to its tight regulation. To address this, we generated cell and mouse models that express a bif...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0905abde-b16f-5bce-a7e6-6613fa13f579
DOI: 10.1101/2024.01.08.574722

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A mouse model to study glutathione limitation <i>in vivo</i>DOI 10.1101/2024.01.08.574722Read

Genetically altered mice to evaluate glutathione homeostasis in health and disease.Semantic proximity Read

Glutathione synthetase deficiency.Semantic proximity Read

Quantification of glutathione with high throughput live-cell imagingSemantic proximity Read

Laboratory evolution of glutathione biosynthesis reveals natural compensatory pathways.Semantic proximity Read

The role of glutathione for oxidative stress and pathogenicity of Streptococcus suisSemantic proximity Read

Deciphering pathophysiological mechanisms underlying cystathionine beta-synthase-deficient homocystinuria using targeted metabolomics, liver proteomics, sphingolipidomics and analysis of mitochondrial functionSemantic proximity Read

Thiol reductive stress activates the hypoxia response pathwaySemantic proximity Read

Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradationSemantic proximity Read

The Expression and Activity of Rhodanese, 3-Mercaptopyruvate Sulfurtransferase, Cystathionine γ-Lyase in the Most Frequently Chosen Cellular Research Models.Semantic proximity Read

Essential role for Ggct in erythrocyte antioxidant defenseSemantic proximity Read

Metabolic engineering of <i>Escherichia coli</i> to modulate hydrogen sulfide levels in the mammalian gutSemantic proximity Read

Mechanism-based inhibition of human persulfide dioxygenase by γ-glutamyl-homocysteinyl-glycine.Semantic proximity Read