Article
The metallothionein-null phenotype is associated with heightened sensitivity to lead toxicity and an inability to form inclusion bodies.
The American journal of pathology - 1 Mar 2002
Qu Wei, Diwan Bhalchandra A, Liu Jie, Goyer Robert A, Dawson Tammy, Horton John L, Cherian M George, Waalkes Michael P
Abstract excerpt
Susceptibility to lead toxicity in MT-null mice and cells, lacking the major forms of the metallothionein (MT) gene, was compared to wild-type (WT) mice or cells. Male MT-null and WT mice received lead in the drinking water (0 to 4000 ppm) for 10 to 20 weeks. Lead did not alter body weight in any group. Unlike WT mice, lead-treated MT-null mice showed dose-related nephromegaly. In addition, after lead exposure...
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