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Article

Metallothionein-null mice are more susceptible than wild-type mice to chronic CdCl(2)-induced bone injury.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Jul 2000

Habeebu S S, Liu J, Liu Y, Klaassen C D

Abstract excerpt

Cadmium (Cd) is an environmental pollutant and is toxic to a number of organs. Chronic exposure to Cd causes loss of bone mass and increased incidence of bone fractures, as seen in Itai-itai patients and laboratory animals. Metallothionein (MT), a low-molecular weight, cysteine-rich, metal-binding protein, has been shown to play an important role in the detoxication of Cd. Thus, this study was designed to test...

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Identifiers

PMID: 10869470
DOI: 10.1093/toxsci/56.1.211

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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