Article
Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium.
Proceedings of the National Academy of Sciences of the United States of America - 18 Jan 1994
Masters B A, Kelly E J, Quaife C J, Brinster R L, Palmiter R D
Abstract excerpt
We inactivated the mouse metallothionein (MT)-I and MT-II genes in embryonic stem cells and generated mice homozygous for these mutant alleles. These mice were viable and reproduced normally when reared under normal laboratory conditions. They were, however, more susceptible to hepatic poisoning...
Topics
- Alanine Transaminase
- Alleles
- Amino Acid Sequence
- Animals
- Aspartate Aminotransferases
- Base Sequence
- Cadmium Poisoning
- DNA
- Female
- Liver
- Male
- Metallothionein
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Molecular Sequence Data
- Mutagenesis, Insertional
- Protein Biosynthesis