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Article

Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium.

Proceedings of the National Academy of Sciences of the United States of America - 18 Jan 1994

Masters B A, Kelly E J, Quaife C J, Brinster R L, Palmiter R D

Abstract excerpt

We inactivated the mouse metallothionein (MT)-I and MT-II genes in embryonic stem cells and generated mice homozygous for these mutant alleles. These mice were viable and reproduced normally when reared under normal laboratory conditions. They were, however, more susceptible to hepatic poisoning by cadmium. This proves that these widely expressed MTs are not essential for development but that they do protect...

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PMID: 8290567
DOI: 10.1073/pnas.91.2.584
PMCID: PMC42993

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