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Article

Targeted disruption of the mouse ferrochelatase gene producing an exon 10 deletion.

Biochimica et biophysica acta - 6 Jan 1999

Magness S T, Brenner D A

Abstract excerpt

Protoporphyria is a disease characterized by a deficiency in ferrochelatase, the terminal enzyme in the heme biosynthetic pathway, which catalyzes the chelation of iron and protoporphyrin to form heme. Clinical symptoms arise from an accumulation of protoporphyrin behind the partial enzyme block and include photosensitivity and sometimes hepatobiliary disease. Protoporphyria is described as an dominant disease,...

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Source

Identifiers

PMID: 9989256
DOI: 10.1016/s0925-4439(98)00096-9

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Targeted disruption of the mouse ferrochelatase gene producing an exon 10 deletion.PMID 9989256Read ↗

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