Article
The apolipoprotein epsilon 4 allele in patients with Alzheimer's disease.
Annals of neurology - 1 Nov 1993
Mayeux R, Stern Y, Ottman R, Tatemichi T K, Tang M X, Maestre G, Ngai C, Tycko B, Ginsberg H
Abstract excerpt
Apolipoprotein E (APO-E) binds to the beta-amyloid peptide and is present in senile neuritic plaques in Alzheimer's disease (AD). The epsilon 4 isoform of APO-E has been associated with both sporadic and familial late-onset AD, implying a causal role. Among patients and control subjects similar in age, gender, and ethnic group from the New York City community of Washington Heights-Inwood, we found that the odds...
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