Article
The apolipoprotein epsilon 4 allele in patients with Alzheimer's disease.
Annals of neurology - 1 Nov 1993
Mayeux R, Stern Y, Ottman R, Tatemichi T K, Tang M X, Maestre G, Ngai C, Tycko B, Ginsberg H
Abstract excerpt
Apolipoprotein E (APO-E) binds to the beta-amyloid peptide and is present in senile neuritic plaques in Alzheimer's disease (AD). The epsilon 4 isoform of APO-E has been associated with both sporadic and familial late-onset AD, implying a causal role. Among patients and control subjects similar i...
Topics
- Aged
- Alleles
- Alzheimer Disease
- Apolipoproteins E
- Black People
- Confidence Intervals
- Family
- Female
- Gene Amplification
- Genetic Linkage
- Genotype
- Hispanic or Latino
- Humans
- Male
- Odds Ratio
- Reference Values
- White People